Aubagio® (teriflunomide)

The active ingredient is teriflunomide. Aubagio works by selectively interfering with the ability of white  blood cells (lymphocytes) to produce the disease response and nerve damage that ultimately leads to relapses.

Aubagio has been shown to reduce or decrease the number of relapses and slow down the progression of physical disability in patients with relapsing forms of MS. Although it is not a cure, patients treated with Aubagio generally find they will have fewer relapses.

Benefits shown in clinical trials

In a major clinical trial, Aubagio 14 mg demonstrated a significant positive effect compared with placebo on the 3 measures of MS disease activity:

  • Slowing of disability progression
  • Fewer brain lesions on MRI
  • Reduction of relapses

How is Aubagio administered?  

Aubagio is a small 14mg tablet that is taken once daily with or without food. It should be taken at the same time each day and with a glass of water.

What are important considerations while taking Aubagio?

Family planning:

  • Aubagio should not be taken if you are pregnant or breastfeeding.
  • For women of childbearing age, it is essential that you use reliable and effective contraception. For more information on effective contraception, contact your healthcare professional or family planning association.
  • If you become pregnant or wish to have children, speak to your doctor straight away.

You should tell your doctor:

  • If you have any allergies or experience an allergic reaction, in case this affects your ability to take Aubagio.
  • If you have or have had any medical conditions, including liver problems, high blood pressure, tuberculosis, kidney disease, chronic or serious infections, a decreased white blood cell count or an illness that lowers your body’s resistance to disease.
  • About any other medicines (tablets and injections) and herbal or vitamin supplements you are taking, or plan to take
  • If you need to have a vaccination while taking Aubagio or during the first 6 months after stopping treatment with Aubagio. Live vaccines are not recommended during treatment with Aubagio.

Side Effects?

Aubagio helps most people with relapsing forms of MS, but it may have unwanted side effects although not everybody gets them.

Tell your doctor or pharmacist if you notice any of the following and they worry you:

  • Diarrhoea
  • Rashes, itchy skin
  • Hair loss  
  • Unusual tiredness or weakness
  • Numbness or tingling of hands or feet
  • Weight loss

These are the more common side effects of Aubagio.
  • Tell your doctor immediately, or go to accident and emergency at your nearest
  • hospital if you notice any of the following:
  • Signs and symptoms of severe infection e.g Fever
  • Severe upper stomach pain, often with nausea and vomiting
  • Severe skin rash or sores in your mouth    Your skin becomes pale, you start to feel tired, you become prone to infections or bruising
  • If you develop new or worsening symptoms such as cough or trouble breathing, with or without a fever

These may be serious side effects of Aubagio and you may need urgent medical attention.

Serious side effects are uncommon. If any of the following happen, stop taking this medicine and tell your doctor immediately, or go to accident and emergency at your nearest hospital:
  • Swelling of the face, lips, mouth or throat, which may cause difficulty in swallowing or breathing
  • Hives
  • Fainting   
  • Yellowing of the skin and eyes (jaundice)
  • Thickened patches of red skin

These are very serious side effects. If you have them, you may have had a serious allergic reaction to Aubagio.
You may need urgent medical attention or hospitalisation. Tell your doctor or pharmacist if you notice anything else that is making you feel unwell.

For more information about Aubagio see:

Medsafe Information Sheet -

Aubagio Website -